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Boost Medical Science UPSC Examination MAINS syllabus

UPSC Medical Science Syllabus IAS Mains Medical Science Syllabus - Boost Medical Science UPSC Examination MAINS syllabus

Medical Science UPSC Examination MAINS syllabus

Paper I


  • Human Anatomy
  • Gross and microscopic anatomy and movements of shoulder, hip and knee joints; Blood supply, nerve innervations of hand, Lymphatic system; Karyotyping, medical genetics; Electron microscopic structure of glomerulus and muscle; Gross and microscopic anatomy and blood supply of lungs, heart, kidneys, liver, testis and uterus; Gross anatomy of pelvis, perineum and inguinal region. Cross-sectional anatomy of the body and mid-thoracic, upper abdominal, mid-abdominal and pelvic regions.
  • Embryology: Major steps in the development of lung, heart, kidney, urinary bladder, uterus, ovary, testis and their common congenital abnormalities; Placenta and placental barrier.
  1. Anatomy of central and peripheral autonomic nervous system :
  • Neural pathways for cutaneous sensations and vision; Cranial nerves, distribution and clinical significance; Anatomy of autonomic control of gastrointestinal, respiratory and reproductive systems.
  1. Human Physiology
  • Central, peripheral and autonomic nervous. system; Nerve and muscle excitation, conduction and transmission of impulse, mechanism of contraction, neurovascular transmission, EMG; Synaptic transmission, reflexes, control of equilibrium, posture and muscle tone descending pathways, functions of cerebellum, basal ganglia, reticular formation, hypothalamus limbic system and cerebral cortex; Physiology of sleep and consciousness, EEG.; Higher functions of the brain; Vision and hearing.
  • Endocrine system: Mechanism of action of hormones, formation, secretion, transport, metabolism, functions and regulations of secretion of pancreas and pituitary glands.
  • Physiology of reproductive system: menstrual cycle, lactation, pregnancy.
  • Blood: Development, regulations and fate of blood cells.
  • Cardiovascular, respiratory gastrointestinal and renal physiology: Cardiac excitation, spread of cardiac impulse, ECG., cardiac output, blood pressure, regulation of cardiovascular functions; Mechanics of respiration and regulation of respiration; Digestion and absorption of food, regulation of secretion and motility of gastrointestinal tract; Glomerular and tubular functions of kidney.
  1. Biochemistry
  • pH and pKA Henderson-Hasselbalch Equation; Properties and regulation of enzyme activity, role of high energy phosphates in bioenergetics; Sources, daily requirements, action and toxicity of vitamins; Metabolism of lipids, carbohydrates, proteins, disorders of their metabolism; Chemical nature, structure, synthesis and functions of nucleic acids and proteins; Distribution and regulation of body water and minerals including trace elements; Blood Gas Analysis, GTT, Immuno electrophoresis, molecular structure of muscle contractile protein, estrogen receptors.

Section B


  • Reaction of cell and tissue of injury, inflammation and repair, disturbances of growth and cancer. genetic diseases; Pathogenesis and histopathology of Rheumatic and ischemic heart disease; Bronchogenic carcinoma, carcinoma breast, oral cancer, cancer colon.
  • Lymphoma, leukaemia, liver cancer, meningioma and meningitis; Etiology, pathogenesis and histopathology of – Peptic ulcer, cirrhosis liver glomerulonephritis, lobar pneumonia, acute osteomyelitis, hepatitis, acute pancreatitis.


  • Growth of microorganisms, sterilization and disinfection, bacterial genetics, virus-cell interactions; Immunological principles, acquired immunity, immunity in infections caused by viruses; Diseases caused by and laboratory diagnosis of Staphylococcus, enterococcus, salmonella, shigella, seche ichiza, pseudomonas, vibrio, adenoviruses, herpes viruses (including rubella_, fungi, protozoa, helminths, leptospiral infection.


  • Drug receptor instruction, mechanism of drug action; Mechanism of action, dosage, metabolism and side effects of – Pilocarpine, terbutaline, metoprolol diazepam, acetylsalicylic acid, ibuprofen, furosemide, metronidazole. Chloroquine. Mechanism of action, dosage and toxicity of- Ampicillin, Cephalosporins, 1,2,3,4,th generations, Aminoglycoside, Doxycycline, chloramphenicol, rifampin, Calcium channel blocker, beta blocker, ace inhibitors, immunosuppressive therapy.
  • Indications, dosage, side-effects and contraindications of- Methotrexate, vincristine, tamoxifen. Classification, route of administration, mechanism of action and side effects of – General anesthetics, hypnotics, analgesics, Anti-viral, anti-fungal drugs.
  1. Forensic Medicine and Toxicology

Forensic examination of injuries and wounds; Physical and chemical examination of blood and seminal stains; Organophosphorus poisoning, sedative overdose, hanging, drowning, burns, snake envenomation.

Paper II

Section A

  1. General Medicine: Etiology, clinical features, diagnosis and principles of management (including prevention) of:
  • Malaria, Typhoid, Cholera, Tetanus, Rabies, Exanthematous Fevers, Tuberculosis, AIDS.
  • Rheumatic, ischemic and congenital heart disease, hypertension. Cardiomyopathy, pulmonary embolism.
  • Acute and chronic respiratory infections, bronchial asthma.
  • Occupational lung disease, pleural effusion, disseminated tuberculosis Malabsorption syndromes, acid peptic diseases, haematemesis. Viral hepatitis, cirrhosis of liver, alcoholic liver disease.
  • Acute glomerulonephritis, chronic pyelonephritis, renal failure, nephrotic syndrome, renovascular hypertension, diabetes mellitus, anemia, coagulation disorders, leukemia, polycythemia and hyperviscosity syndrome, meningitis encephalitis, cerebrovascular diseases.
  • Role of Imageology in the workup of medical problems, ultrasound, echocardiogram, CT scan MRI.
  • Psychiatry: Common psychiatric disorders, schizophrenia. ECT, lithium.


  • Common pediatric problems, congenital cyanotic heart disease, respiratory distress syndrome, broncho pneumonias, kernicterus. Aids- prevention of vertical transmission.


  • Common skin diseases, psoriasis, Hansen’s disease, fungal dermatitis, scabies, eczema, vitiligo, Stevan Johnsons syndrome.

Section B

1.General Surgery: Clinical features, causes diagnosis and principles of management of:

  • Cervical lymph node enlargement, parotid tumor, oral cancer, cleft palate, hare lip.
  • Laryngeal tumor, esophageal tumors.
  • Peripheral arterial diseases, varicose veins, coarctation of aorta.
  • Dysfunctions of thyroid parathyroids and adrenals.
  • Tumors of Thyroid, Parathyroid, Adrenal, Pituitary Glands.
  • Abscess of breast, cancer breast, fibroadenoma and adenosis.
  • Acute and chronic appendicitis, bleeding peptic ulcer, tuberculosis of bowel, intestinal obstruction, ulcerative colitis.
  • Renal mass, acute retention of urine, benign prostatic hypertrophy.
  • Haemothorax, constrictive pericarditis.
  • Splenomegaly, chronic cholecystitis, portal hypertension, liver abscess, peritonitis, carcinoma head of pancreas.
  • Direct and indirect inguinal hernias and their complications.
  • Fractures of femur and spine, Colles’ fracture and bone tumors.
  • Organ transplantation, kidney, liver, heart, bone-marrow.
  • Laparoscopic Surgery.
  1. Obstetrics and gynecology including Family Planning
  • Diagnosis of pregnancy, screening of high risk pregnancy, foetal placental development.
  • Labour management, complications of 3rd stage, postpartum haemorrhage, resuscitation of the newborn.
  • Diagnosis and management of anaemia and pregnancy induced hypertension.
  • Principles of the following contraceptive methods: Intrauterine devices, pills, tubectomy and vasectomy.
  • Medical termination of pregnancy including legal aspects.
  • Etiology, clinical features, diagnosis and principles of management of: Cancer cervix, Leucorrhoea, pelvic pain, infertility, abnormal uterine bleeding, menorrhagia.
  1. Preventive and Social medicine
  • Concept of causation and control of disease in the community, principles and methods of epidemiology.
  • Health hazards due to environmental pollution and industrialisation.
  • Normal nutrition and nutritional deficiency diseases in India.
  • Population trends (World and India),
  • Growth of population and its effect on health and development.
  • Objectives, components and critical analysis of each of the following National programmes for the control/eradication of:
  • Malaria, filaria, kala-azar, leprosy, tuberculosis, cancer, blindness, iodine deficiency disease, AIDS & STD and guinea worm.
  • Objectives, components critical analysis of each of the following national Health and Family Welfare Programmes:
  • Maternal and child health
  • Family welfare
  • Nutrition
  • Immunization

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